Self-Assembled Thermoresponsive Polymeric Nanogels for 19F MR Imaging
| Autor: | David Babuka, Miroslav Šlouf, Ondrej Sedlacek, Rafał Konefał, Jan Kotek, Daniel Jirák, Martin Hruby, Kristyna Kolouchova, Jiri Trousil, Bohumila Podhorská, Jan Blahut, Olga Janoušková, Martin Vit |
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| Rok vydání: | 2018 |
| Předmět: |
Aqueous solution
Materials science Polymers and Plastics Bioengineering 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Mr imaging 0104 chemical sciences Self assembled Biomaterials chemistry.chemical_compound Chemical engineering chemistry Acrylamide Materials Chemistry Copolymer Methacrylamide Particle size 0210 nano-technology Nanogel |
| Zdroj: | Biomacromolecules. 19:3515-3524 |
| ISSN: | 1526-4602 1525-7797 |
| Popis: | Magnetic resonance imaging using fluorinated contrast agents (19F MRI) enables to achive highcontrast in images due to the negligible fluorine background in living tissues. In this pilot study, we developed new biocompatible, temperature-responsive, and easily synthesized polymeric nanogels containing a sufficient concentration of magnetically equivalent fluorine atoms for 19F MRI purposes. The structure of the nanogels is based on amphiphilic copolymers containing two blocks, a hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) or poly(2-methyl-2-oxazoline) (PMeOx) block, and a thermoresponsive poly[N(2,2difluoroethyl)acrylamide] (PDFEA) block. The thermoresponsive properties of the PDFEA block allow us to control the process of nanogel self-assembly upon its heating in an aqueous solution. Particle size depends on the copolymer composition, and the most promising copolymers with longer thermoresponsive blocks form nanogels of suitable size for angiogenesis imaging or the labeling of cells (appr... |
| Databáze: | OpenAIRE |
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