Dissociation equilibrium between uncharged and charged local anesthetic lidocaine in a surface-adsorbed film

Autor: Ikuo Ueda, Shoji Kaneshina, Hiroshi Kamaya, Michio Yamanaka, Hitoshi Matsuki
Rok vydání: 2004
Předmět:
Zdroj: Colloid and Polymer Science. 283:512-520
ISSN: 1435-1536
0303-402X
DOI: 10.1007/s00396-004-1177-1
Popis: The dissociation equilibrium between uncharged local anesthetic lidocaine (LC) and charged local anesthetic LC (LC•H+) in a surface-adsorbed film was investigated by measuring the surface tension and pH of aqueous solutions of a mixture of hydrochloric acid and LC. The surface tension values decreased slightly with increasing total molality mt at 0≤X2≤0.5, where X2 is the mole fraction of LC in the mixture, while they decreased rapidly with increasing mt at 0.5
Databáze: OpenAIRE