| Autor: |
Hong-Gu Lee, Byung-Wook Cho, Seon-Ku Kim, Taek-Soon Shin, Hae-Yeal Jeon, Ki-Duk Song, Sang-Wook Kim, Mi-Rang Lee, Han-Seok Gang |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Journal of Life Science. 18:731-737 |
| ISSN: |
1225-9918 |
| DOI: |
10.5352/jls.2008.18.5.731 |
| Popis: |
T cells develop in thymus, where immature progenitors undergo multi-stage developmental processes until mature CD4+ and CD8+ single positive T cells are generated and egress out to the periphery. Signals from T cell receptor are pivotal for T cell development in thymus as well as in periphery. Gene targeted mutant mice have contributed the understanding underlying mechanisms by dissecting the signaling pathways which governing these complex processes. Development of refined mutational system will be imperative to analyze the signaling pathways by taking consideration of context of ‘timing and/or space’ of gene function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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