Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
| Autor: | Bryant, JM, Grogono, DM, Rodriguez-Rincon, D, Everall, I, Brown, KP, Moreno, P, Verma, D, Hill, E, Drijkoningen, J, Gilligan, P, Esther, CR, Noone, PG, Giddings, O, Bell, SC, Thomson, R, Wainwright, CE, Coulter, C, Pandey, S, Wood, ME, Stockwell, RE, Ramsay, KA, Sherrard, LJ, Kidd, TJ, Jabbour, N, Johnson, GR, Knibbs, LD, Morawska, L, Sly, PD, Jones, A, Bilton, D, Laurenson, I, Ruddy, M, Bourke, S, Bowler, ICJW, Chapman, SJ, Clayton, A, Cullen, M, Dempsey, O, Denton, M, Desai, M, Drew, RJ, Edenborough, F, Evans, J, Folb, J, Daniels, T, Humphrey, H, Isalska, B, Jensen-Fangel, S, Jönsson, B, Jones, AM, Katzenstein, TL, Lillebaek, T, MacGregor, G, Mayell, S, Millar, M, Modha, D, Nash, EF, O'Brien, C, O'Brien, D, Ohri, C, Pao, CS, Peckham, D, Perrin, F, Perry, A, Pressler, T, Prtak, L, Qvist, T, Robb, A, Rodgers, H, Schaffer, K, Shafi, N, Van Ingen, J, Walshaw, M, Watson, D, West, N, Whitehouse, J, Haworth, CS, Harris, Ordway, D, Parkhill, J, Floto, RA |
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| Jazyk: | angličtina |
| Předmět: |
Cystic Fibrosis
Incidence Mycobacterium Infections Nontuberculous Nontuberculous Mycobacteria Genomics Mice SCID Sequence Analysis DNA bacterial infections and mycoses Communicable Diseases Emerging Polymorphism Single Nucleotide 3. Good health Mice Drug Resistance Multiple Bacterial Pneumonia Bacterial bacteria Animals Humans Lung Genome Bacterial Phylogeny |
| Popis: | Lung infections with $\textit{Mycobacterium abscessus}$, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom $\textit{M. abscessus}$ accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, $\textit{M. abscessus}$ was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of $\textit{M. abscessus}$ infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge. |
| Databáze: | OpenAIRE |
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