Tetrabutylammonium tosylate as inert phase-transfer catalyst: The key to high efficiency SN2 radiofluorinations
| Autor: | Olga A. Fedorova, Vasilii Timofeev, Viktoriya Orlovskaya, Dmitrii Antuganov, Raisa Krasikova |
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| Rok vydání: | 2020 |
| Předmět: |
Inert
Radiation Materials science Compatibility (geochemistry) 010403 inorganic & nuclear chemistry 01 natural sciences 030218 nuclear medicine & medical imaging 0104 chemical sciences 03 medical and health sciences Cartridge 0302 clinical medicine Chemical engineering SN2 reaction Phase-transfer catalyst |
| Zdroj: | Applied Radiation and Isotopes. 163:109195 |
| ISSN: | 0969-8043 |
| Popis: | Here we describe use of the tetrabutylammonium p-toluenesulfonate (TBAOTs) as an inert phase transfer catalyst allowing high efficient aliphatic radiofluorination of labeling precursors for the preparation of common radiotracers using only 0.2–1.2 mg of the substrates. With operational convenience (no need for azeotropic drying) and compatibility with the common types of strong anion-exchange cartridges (QMA), this method has a high potential for routine application in various automated synthesizers and offers significant costs reductions due to less precursors used. |
| Databáze: | OpenAIRE |
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