Aerosolized type II transmembrane serine protease 2 inhibitor to combat COVID-19: a proposal

Autor:	Surajit Bhattacharjee, Chandan Raybarman
Rok vydání:	2021
Předmět:	Serine protease Coronavirus disease 2019 (COVID-19) biology business.industry biology.protein Medicine urologic and male genital diseases business Transmembrane protein Aerosolization Microbiology
Zdroj:	International Journal of Contemporary Pediatrics. 8:1996
ISSN:	2349-3291 2349-3283
DOI:	10.18203/2349-3291.ijcp20214544
Popis:	Type II transmembrane serine protease (TMPRSS2) is expressed at the cell surface with COVID-19 infection. And COVID-19 infection misuse TMPRSS2 to advance their spread, making this protease potential focuses for intervention in COVID-19 infection. TMPRSS2 blocker may be the appropriate option to arrest cellular entry of COVID-19 by deregulating spike priming. Therefore a trial may be intended to watch the adequacy of aerosolized spraying of TMPRSS2 inhibitors to break the viral entry to the objective cells that empower to break the COVID-19 transmission. Targeting TMPRSS2 through aerosolized TMPRSS2 inhibitor is important to examine a possibly viable remedial technique in the treatment of COVID-19.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1466e7aad0cea5a1ec41475f1d606443 https://doi.org/10.18203/2349-3291.ijcp20214544 Zobrazit plný text záznamu