Crystal Structure of Levofloxacin Anhydrates: A High-Temperature Powder X-ray Diffraction Study Versus Crystal Structure Prediction
| Autor: | Jennifer Tavares Jacon Freitas, Cristiane C. de Melo, Fabio Furlan Ferreira, Olimpia Maria Martins Santos Viana, Antonio C. Doriguetto |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Thermogravimetric analysis
Polarized light microscopy Materials science 02 engineering and technology General Chemistry Crystal structure 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Crystal structure prediction Crystallography Differential scanning calorimetry X-ray crystallography Anhydrous General Materials Science 0210 nano-technology Hydrate |
| Zdroj: | Crystal Growth & Design. 18:3558-3568 |
| ISSN: | 1528-7505 1528-7483 |
| DOI: | 10.1021/acs.cgd.8b00363 |
| Popis: | Levofloxacin, the levo-isomer of the antibiotic ofloxacin, can crystallize into two different hydrate forms, the monohydrate and the hemihydrate. Although these forms are well characterized, little is known about their anhydrous structures besides the study of Singh and Thakur using crystal structure prediction. In order to solve this issue, this paper proposes the use of high-temperature powder X-ray diffraction to determine the anhydrous structures of the levofloxacin forms termed in the literature as α and γ, herein obtained by heating of the levofloxacin monohydrate and hemihydrate, respectively. These are the first levofloxacin anhydrates whose structures could be solved. To support our results, the dehydration process has been also evaluated by means of differential scanning calorimetry, thermogravimetric analysis, and hot-stage polarized microscopy. The resulting X-ray structures differ from the ones reported as the best-predicted solution, although the predicted work had predicted similar structur... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|