| Popis: |
Was investigated a peptide named L12P obtained from human immunoglobulin Lambda joining 1 (IGLJ1) before recombination. The peptide previously showed activity against fungi, which motivated us to investigate the antitumoral activity against murine B16F10 melanoma tumor cells. To test the biological activity of the peptide against tumor cells different tumor phenotypes were initially assayed in vitro, such as migration, adherence and cell cycle. Hence, the selected peptide displayed significant action in vitro against melanoma cells. In conclusion the present work may suggest a functional molecules derived from immunoglobulin with future potential therapeutic. |
