Selectivity ofmeso-tetra(hydroxyphenyl)porphyrins and chlorins and of photofrin II in causing photodamage in tumour, skin, muscle and bladder. The comcept of cost-benefit in analysing the results

Autor: M. Ruston, S. L. Akande-Adebakin, M. C. Berenbaum, E. B. Chevretton, R. Bonnett
Rok vydání: 1993
Předmět:
Zdroj: Lasers in Medical Science. 8:235-243
ISSN: 1435-604X
0268-8921
DOI: 10.1007/bf02547845
Popis: The selectivities of Photofrin II (Ph II) and four new photosensitizers for tumour and normal tissues have been compared by cost-benefit analysis. Mice were given tetra(p-hydroxyphenyl)porphyrin (p-THPP) or tetra(m-hydroxyphenyl)porphyrin (m-THPP) or the corresponding chlorins (p-THPC, m-THPC, respectively) or Ph II. Twenty-four hours later, tumour (PC6) or normal skin, muscle and bladder were illuminated with 10 J cm−2 light from a dye laser at the appropriate wavelengths. Damage indices were (i) depth of tumour necrosis, (ii) oedema measured by increase in weight of skin, muscle and bladder, (iii) extravasation of systemically administered Evans blue into skin and bladder and (iv) muscle necrosis. Dose-response curves were constructed and selectivities compared by determining the level of benefit (depth of tumour necrosis) obtained for specific costs (damage to normal tissue). m-THPC was by far the most selective for tumour compared with normal tissues and Ph II the least. For example, for a cost in oedema that doubled skin weight, the depth of tumour necrosis was 1.1 mm for Ph II, 3 mm for p-THPP, 4.1 mm for m-THPP, 5.6 mm for p-THPC, and 6.3 mm for m-THPC. m-THPC appears to be a promising sensitizer for clinical investigation.
Databáze: OpenAIRE
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