Synthesis of Triazolylisatins Glycoconjugates and Some Ammonium Hydrazones on Their Basis

Autor:	Andrei V. Bogdanov, Vladimir F. Mironov, A. D. Voloshina, Olga V. Andreeva, K. I. Enikeeva, A. V. Samorodov, Mayya G Belenok
Rok vydání:	2021
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Residue (chemistry) chemistry Glycoconjugate Isatin Cationic polymerization Click chemistry Ammonium General Chemistry Carbohydrate Ring (chemistry) Combinatorial chemistry
Zdroj:	Russian Journal of General Chemistry. 91:1282-1291
ISSN:	1608-3350 1070-3632
Popis:	The click reaction of propargylisatins with some azido-sugars was used to synthesize new isatin derivatives, in which the carbohydrate residue is linked to the 2,3-dioxindole scaffold via the 1,2,3-triazole ring. A number of water-soluble acylhydrazones with various structure of cationic fragment were obtained on their basis. It was shown that the newly obtained compounds do not exhibit hemotoxic action and have a significant antiaggregatory and anticoagulant activity at the level of reference drugs such as acetylsalicylic acid and pentoxifylline.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::14488131b7bba9f9d68244d94f680302 https://doi.org/10.1134/s1070363221070045 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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