Predictive Value of Hepatitis B Surface Antigen and Gamma-Glutamyl Transpeptidase for Significant Liver Fibrosis Among Patients with Immune-Tolerant Phase Chronic Hepatitis B

Autor: Zu-Xiong Huang, Yu-Rui Liu, Na-Ling Kang, Meng-Xin Lin, Jing Dong, Jie-Min Zhang, Da-Wu Zeng, Yueyong Zhu
Rok vydání: 2019
Předmět:
Zdroj: SSRN Electronic Journal.
ISSN: 1556-5068
Popis: Background: Hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) in the immune-tolerant (IT) phase is significantly associated with high risk for hepatocellular carcinoma (HCC), suggesting requirement for antiviral therapy particularly for those with histological liver injury. This study aimed to develop a noninvasive model to predict significant liver fibrosis among IT-phase CHB patients. Methods: 113 IT-phase CHB patients were retrospectively recruited and divided into two histopathological groups according to their histological profiles: necroinflammatory score
Databáze: OpenAIRE