ChemInform Abstract: Peptidomimetics via Copper-Catalyzed Azide—Alkyne Cycloadditions

Autor:	Kevin Burgess, Yu Angell
Rok vydání:	2008
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Chemistry Peptidomimetic Copper catalyzed Click chemistry Alkyne Peptide General Medicine Azide Combinatorial chemistry Protein secondary structure
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200801239
Popis:	This critical review concerns the impact of copper-mediated alkyne–azide cycloadditions on peptidomimetic studies. It discusses how this reaction has been used to insert triazoles into peptide chains, to link peptides to other functionalities (e.g. carbohydrates, polymers, and labels), and as a basis for evolution of less peptidic compounds as pharmaceutical leads. It will be of interest to those studying this click reaction, peptidomimetic secondary structure and function, and to medicinal chemists.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::143d8ce892d258ad8faa6e6a5f1d7fee https://doi.org/10.1002/chin.200801239 Zobrazit plný text záznamu Plný text