Comparative study of fluticasone propionate combined with azelastine versus fluticasone propionate alone as nasal spray in allergic rhinitis
| Autor: | Santosh Malashetti, Prabhu Khavasi, S H Chandrashekharayya, H C Dhanush |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | International Journal of Otorhinolaryngology and Head and Neck Surgery. 7:487 |
| ISSN: | 2454-5937 2454-5929 |
| DOI: | 10.18203/issn.2454-5929.ijohns20210683 |
| Popis: | Background: Allergic rhinitis (AR) is a symptomatic disorder of the nose induced after allergen exposure due to an IgE-mediated inflammation of membranes lining the nose. Allergic rhinitis is subdivided into intermittent (IAR) or persistent (PER) disease and the severity into mild or moderate/severe. The most widely used and effective medications to treat allergic rhinitis are oral or topical antihistamines and topical nasal steroids.Methods: This prospective case series study included 80 patients of PER divided randomly in to 2 groups of 40 each with group 1 receiving fluticasone propionate and azelastine and group 2 receiving fluticasone propionate alone. Individual symptom scores and total symptom score (TSS) were recorded before treatment and after 4 weeks of treatment.Results: The difference in mean TSS before and after 4 weeks study period were statistically significant in both groups (pConclusions: In allergic rhinitis, both fluticasone propionate + azelastine nasal spray and fluticasone propionate nasal spray are effective in relieving symptoms. But, fluticasone propionate and azelastine has significant reduction of symptoms when compared with fluticasone propionate alone. |
| Databáze: | OpenAIRE |
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