Evaluation of Larvicidal andin Vitro. Antiparasitic Activities of Plants in a Biodiversity Plot in the Altos de Campana National Park, Panama
| Autor: | Mahabir P. Gupta, Reto Brun, Angela I. Calderón, Eduardo Ortega-Barria, Luz I. Romero, D A Mireya Correa |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pharmacology
Panama biology Traditional medicine Antiparasitic medicine.drug_class Pharmaceutical Science Plasmodium falciparum General Medicine Aedes aegypti Piper fimbriulatum Pharmacognosy biology.organism_classification Leishmania mexicana Complementary and alternative medicine Drug Discovery Botany medicine Molecular Medicine Trypanosoma cruzi |
| Zdroj: | Pharmaceutical Biology. 44:487-498 |
| ISSN: | 1744-5116 1388-0209 |
| Popis: | This TDR/WHO project was carried out from 2003 to 2005 in an 0.1-ha biodiversity plot in the Altos de Campana National Park to discover novel active antiparasitic and larvicidal compounds in Panamanian plants. One-hundred-fifty organic plant extracts representing 43 families, 73 genera, and 93 species were tested in a panel of antimalarial (Plasmodium falciparum. W2, chloroquine resistant), antileishmanial (Leishmania mexicana. amastigotes), antitrypanosomal (Trypanosoma cruzi. trypomastigotes), and larvicidal (Aedes aegypti.) screens. Of these 150 plant extracts, two (1.3%) (Talisia nervosa. and Topobea parasitica.) showed significant antimalarial activity (IC50 values < 10 µg/ml), two (1.3%) (Cestrum megalophyllum. and Zanthoxylum acuminatum.) weak antileishmanial activity (IC50 values ranging from 10 to 20 µg/ml), one (0.6%) (Zanthoxylum acuminatum.) weak antitrypanosomal activity (IC50 values ranging from 10 to 20 µg/ml), and one (0.6%) (Piper fimbriulatum.) larvicidal activity (LC100 values |
| Databáze: | OpenAIRE |
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