Heterocyclization of functionalized heterocumulenes with C,N-, C,O-, and C,S-binucleophiles: X. 1-Chloroalkyl isocyanates in the synthesis of new 5-aroyldihydropyrimidines

Autor:	Oleg Kushnir, Mykhailo Vovk, Volodymyr Sukach
Rok vydání:	2009
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Condensation Organic chemistry Isocyanate Combinatorial chemistry
Zdroj:	Russian Journal of Organic Chemistry. 45:755-761
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428009050182
Popis:	Reactions of 1-chlorobenzyl isocyanates with N,S-aroylketene acetals depending on the conditions provide either 5-aroyl-6-methylsulfanyl-3,4-dihyropyrimidin-2(1H)-ones or 5-aroyldihyropyrimidine-2,4(1H,3H)-diones. 1-Aryl-2,2,2-trifluoro-1-chloroethyl isocyanates in a similar condensation gave 5-aroyl-6-methylsulfanyl-2-trifluoromethyl-2,3-dihyropyrimidin-4(1H)-ones.
Databáze:	OpenAIRE
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