Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II

Autor:	Jung-Hyuck Cho, Hyeong Beom Park, Myung-Ho Jung, Chang-Hyun Oh
Rok vydání:	2008
Předmět:	Imipenem Heptane biology Chemistry Stereochemistry General Chemistry Ring (chemistry) biology.organism_classification In vitro Pyrrolidine chemistry.chemical_compound medicine Moiety Antibacterial activity Bacteria medicine.drug
Zdroj:	Bulletin of the Korean Chemical Society. 29:1472-1478
ISSN:	0253-2964
DOI:	10.5012/bkcs.2008.29.8.1472
Popis:	The synthesis of a new series of 1-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compounds were found to be more active compared to imipenem against Gram-negative bacteria. A particular compound (IIIc) having 7-oxo-5- azaspiro[2,4]heptane moiety showed the most potent antibacterial activity.
Databáze:	OpenAIRE
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