| Autor: |
Jørn Herrstedt, Sebastian Werngreen Nielsen |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Diagnosis, Management and Emerging Strategies for Chemotherapy-Induced Neuropathy ISBN: 9783030786625 |
| Popis: |
There are no clinically relevant, evidence-based preventive strategies for chemotherapy-induced peripheral neuropathy (CIPN). In this chapter we discuss how limitations in current animal models lead to insufficient understanding of CIPN pathophysiology and how drug development for neurodegenerative diseases in general suffers because of this. We draw on previous studies of CIPN prevention to reflect upon what can be learned, but this chapter is not a historical account of past CIPN strategies nor it is an exhaustive list of CIPN mechanisms in rodents and mice. There are several succinctly well-written and recent reviews that cover these topics. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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