Abstract P194: Proteomic Analysis of Cardiac Troponin I And T in Older Adults Without Cardiovascular Disease
| Autor: | Olive Tang, Jingsha Chen, Ron C. Hoogeveen, Eric Boerwinkle, Adrienne Tin, James S. Pankow, Josef Coresh, Kunihiro Matsushita, Elizabeth Selvin, Bing Yu, Xiaoming Jia, Christie M. Ballantyne |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Circulation. 141 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Background: Minute elevations in cardiac troponins detected with high sensitivity assays are associated with cardiovascular disease (CVD) and mortality. The biology underlying these associations is uncertain. We identified plasma proteins associated with cardiac troponins and assessed the relation of troponin-associated proteins with CVD and all-cause mortality in adults without prevalent CVD. Methods: We included 3451 adults (62% female, 18% black, mean age: 75 years) in ARIC at Visit 5 (2011-2013). High sensitivity assays were used to measure troponins (hs-cTnI [Abbott], hs-cTnT [Roche]). We used linear regression to model the association of log2-transformed troponin and plasma proteins (SomaLogic aptamer assay). Upstream regulators of the troponin-associated proteins were identified using Ingenuity Pathway Analysis. Elastic net was used to extract troponin-associated protein signatures for principal component analysis and Cox models of CVD and all-cause mortality (median follow-up: 6 years). Results: Of the 4326 plasma proteins, there were 281 significantly (p Conclusions: Hs-cTnI and hs-cTnT have overlapping, but distinct, proteomic signatures. The underlying proteomic signature explains most of the mortality risk associated with hs-cTnT, but not hs-cTnI. |
| Databáze: | OpenAIRE |
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