Effect of lamotrigin on the development of neurogenic pain syndrome in rats

Autor:	V. K. Reshetnyak, E. I. Danilova, V. N. Grafova, V. S. Smirnova, M. L. Kukushkin
Rok vydání:	1998
Předmět:	business.industry Analgesic Chronic pain General Medicine medicine.disease Spinal cord General Biochemistry Genetics and Molecular Biology Pathophysiology Neurogenic pain Dissection Nociception medicine.anatomical_structure Anesthesia medicine Sciatic nerve business
Zdroj:	Bulletin of Experimental Biology and Medicine. 125:457-460
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02445283
Popis:	Analgesic activity of a new anticonvulsive agent lamotrigin was studied on the model of neurogenic pain syndrome produced in rats by penicillin applied to the dorsal surface of the spinal cord and by dissection of the sciatic nerve. Lamotrigin was shown to have a profound analgesic activity. It can be used as an efficient prophylactic agent for prevention of chronic pain syndromes by suppression of the generators of pathologically enhanced excitation in the nociceptive structures which are the pathophysiological basis of the chronic pain syndromes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::140bfb965e5c0875bdc33048ef6dbc20 https://doi.org/10.1007/bf02445283 Zobrazit plný text záznamu Full text from SpringerLink