Der NBT-PABA-Test in der Diagnostik der exokrinen Pankreasinsuffizienz: Ein Vergleich mit dem Sekretin-Pankreozymin-Test, den Stuhlenzym-Bestimmungen und der quantitativen Stuhlfett-Analyse
| Autor: | Paul Georg Lankisch, W. F. Caspary, H. Koop, S. Ehrhardt-Schmelzer |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
business.industry Urinary system chemical and pharmacologic phenomena General Medicine medicine.disease Trypsin Gastroenterology Secretin Excretion fluids and secretions Internal medicine medicine Pancreatitis business Exocrine pancreatic insufficiency Pathological Feces medicine.drug |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 105:1418-1423 |
| ISSN: | 1439-4413 0012-0472 |
| Popis: | The NBT-PABA test, an oral pancreatic function test, was performed in 67 patients with proven chronic pancreatitis (secretin pancreozymin test or intraoperatively) and was pathological in 60 (89.6%). Prolongation of urinary collection period from 6 to 9 hours did not improve the diagnostic value. In comparison with the NBT-PABA test the sensitivity of trypsin and chymotrypsin determination in stool was 40.6% and 62.2%, respectively. In severe exocrine pancreatic insufficiency when pathological fecal fat excretion was demonstrable (steathorrhea) the accuracy of fecal enzyme determination was clearly higher (59.1% and 91.8%, respectively). Thus the NBT-PABA test is an alternative diagnostic tool for exocrine pancreatic insufficiency when the secretin-pancreozymin test, and fecal enzyme and fecal fat determination are too complicated. However, as intact absorption of NBT-PABA is possible, the test only provides a qualitative and limited quantitative evaluation of pancreatic function. |
| Databáze: | OpenAIRE |
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