DNA threading intercalation of enantiopure [Ru(phen)2bidppz]2+ induced by hydrophobic catalysis
| Autor: | Bobo Feng, Elin Sundin, Per Lincoln, Anna K. F. Mårtensson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Intercalation (chemistry) General Physics and Astronomy chemistry.chemical_element Ether Polyethylene glycol 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Ruthenium chemistry.chemical_compound DNA Intercalation Enantiopure drug chemistry Moiety Physical and Theoretical Chemistry DNA |
| Zdroj: | Physical Chemistry Chemical Physics. 23:2238-2244 |
| ISSN: | 1463-9084 1463-9076 |
| Popis: | The enantiomers of a novel mononuclear ruthenium(II) complex [Ru(phen)2bidppz]2+ with an elongated dppz moiety were synthesized. Surprisingly, the complex showed no DNA intercalating capability in an aqueous environment. However, by the addition of water-miscible polyethylene glycol ether PEG-400, self-aggregation of the hydrophobic ruthenium(II) complexes was counter-acted, thus strongly promoting the DNA intercalation binding mode. This mild alteration of the environment surrounding the DNA polymer does not damage or alter the DNA structure but instead enables more efficient binding characterization studies of potential DNA binding drugs. |
| Databáze: | OpenAIRE |
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