Observations on the Antitumor Effect of N-Dichloroacetyl-DL-Serine (FT-9045)

Autor:	I. Levi, H. Blondal, J. P. A. Latour, W. D. Fraser
Rok vydání:	1961
Předmět:	Pathology medicine.medical_specialty Cyclophosphamide Low toxicity business.industry Neoplastic growth Pharmacology Malignant disease Sodium salt Serine Haematopoiesis medicine Radiology Nuclear Medicine and imaging business medicine.drug
Zdroj:	Radiology. 76:945-960
ISSN:	1527-1315 0033-8419
DOI:	10.1148/76.6.945
Popis:	It has been reported recently (1) that the sodium salt of N-dichloroacetyl-DL-serine (FT-9045) inhibited the growth of sarcoma-307 in mice. The tumors were well established and of considerable size (1 to 2 c.c. in volume). The observation that they were sensitive to the compound (while the host animals suffered no obvious ill effects) is of considerable interest. The low toxicity of FT-9045 in animals stands out in contrast to most other chemotherapeutic agents, which depress hematopoiesis and injure other body systems at dose levels which are often ineffective against neoplastic growth. In view of this, it was considered reasonably safe to carry out preliminary studies with FT-9045 on human beings with far-advanced malignant disease. Early in these trials, through a chance observation, it was suspected that an enhanced effect occurred when FT-9045 was used in combination with other antitumor agents. These agents were cyclophosphamide and x-irradiation. This report will include the results of such combina...
Databáze:	OpenAIRE
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