Preparation and properties of 7α-formamido cephalosporins

Autor:	Clive Leslie Branch, Stephen Christopher Finch, Michael J. Pearson, Roger J. Ponsford, Angela W. Guest, Peter H. Milner, Terence C. Smale, Arun C. Kaura
Rok vydání:	1987
Předmět:	chemistry.chemical_compound Bicyclic molecule medicine.drug_class Chemistry Cephalosporin polycyclic compounds medicine Lactam Organic chemistry Amine gas treating Nuclear magnetic resonance spectroscopy Formylation
Zdroj:	J. Chem. Soc., Perkin Trans. 1. :45-55
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19870000045
Popis:	The preparation of novel antibacterially active 7α-formamido cephalosporins from the corresponding 7α-(methylthio) analogues by mercury (II)-mediated displacement with ammonia and subsequent formylation is described. The amine (2), a versatile intermediate, was prepared and acylated to give a wider range of 7α-formamido cephalosporins. Modifications at C-3 are discussed, in particular the preparation of the 3-(heterocyclylthiomethyl) cephalosporin (44) and the 3-(pyridylmethyl) derivative (49).
Databáze:	OpenAIRE
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