Differences in the effects of TRPV1 antagonists on energy metabolism in mice
| Autor: | Ruojun Liang, Shoji Tabata, Jun Hai, Fuminori Kawabata, Shotaro Nishimura, Yuko Kawabata |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chemistry musculoskeletal neural and ocular physiology Energy metabolism TRPV1 Antagonist General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound Transient receptor potential channel 030104 developmental biology 0302 clinical medicine Nociception nervous system Capsaicin lipids (amino acids peptides and proteins) Respiratory system Receptor 030217 neurology & neurosurgery |
| Zdroj: | Biomedical Research. 39:279-286 |
| ISSN: | 1880-313X 0388-6107 |
| DOI: | 10.2220/biomedres.39.279 |
| Popis: | Transient receptor potential vanilloid 1 (TRPV1) is a nociceptive cation channel that is activated by heat, protons and chemical ligands such as capsaicin. We investigated the roles of the capsaicin receptor, TRPV1, in controlling the energy metabolism of the whole body. It has been reported that the activation of TRPV1 by its agonists enhances energy metabolism. In this study, we used a respiratory gas analysis system to examine whether the inhibition of TRPV1 changes energy metabolism in mice. In addition, we examined the contributions of different modes of TRPV1 activation (heat, protons and capsaicin) to determine the influence of 3 different TRPV1 antagonists on energy metabolism. Here, we showed that intragastric administration of AMG517, a nonselective antagonist of TRPV1 (for heat, protons and capsaicin), enhanced energy metabolism as much as did intraperitoneal administration. On the other hand, intraperitoneal administration of AMG9810, a nonselective antagonist like AMG517, enhanced energy expenditure more than intragastric administration. However, the administration of JYL1421, a TRPV1 antagonist that very strongly inhibits TRPV1 activated by capsaicin, did not change energy metabolism. Taken together, these results suggest that the type of TRPV1 antagonists and the routes of its administration have different effects on energy metabolism in a normal body. Surprisingly, co-administration of JYL1421 and capsaicin significantly enhanced the energy metabolism more than administration of capsaicin alone. These results support the possibility that an unconventional mechanism is responsible for the increase in energy metabolism that occurs via TRPV1 inhibition. |
| Databáze: | OpenAIRE |
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