Studies on Anaphylactic Shock in the Mouse
| Autor: | Perry Morgan, Noble P. Sherwood, Alvar A. Werder, Karl Youngstrom |
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| Rok vydání: | 1960 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 84:325-332 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.84.3.325 |
| Popis: | Summary A report is made on the effects of x-irradiation (500 r) on the anaphylactic response of mice sensitized with bovine albumin-adjuvant emulsion and challenged with bovine albumin solution. X-irradiation given 1/12, 2, 4, 6 or 8 days before or 2, 4 or 6 days following sensitization failed to enhance the anaphylactic sensitivity when the interval between sensitization and challenge was 7 days. X-irradiation given 1/12, 2, 4, 6, 8, 10, 12 or 14 days before or 2, 4, 6 or 8 days after sensitization depressed the anaphylactic sensitivity of mice challenged 10 days after sensitization as measured by mortality incidence and changes in rectal temperatures. In general, a depressive effect of x-irradiation on the anaphylactic response was observed in mice exposed 2, 4, 6, 8 or 10 days prior to or 2 days following sensitization when challenge was made 14, 21, 28, 35 or 42 days postsensitization. An enhancement of susceptibility to fatal anaphylaxis was discernible in sensitized animals receiving x-irradiation 4 days or more following sensitization when the interval between sensitization and challenge was 14, 21 or 28 days. No effect of x-ray on mortality incidence or change in rectal temperature was observed when the interval was 35 or 42 days. |
| Databáze: | OpenAIRE |
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