| Autor: |
M Ogero, L Isaaka, L Mumelo, D Kimego, T Njoroge, G Mbevi, C Wanyama, R Lucinde, H Gathuri, M Otiende, C Nzioki, A Wachira, F Mumbi, G Oeri, N Mwangi, R Gitari, D Mugambi, S Namu, A Ithondeka, H Kariuki, Z Kiama, L Mwende, E Jowi, B Muthui, A Kaara, E Sitienei, L Thuranira, I Oginga, J Njagi, E Kamau, E Namulala, G Oketch, O Wandera, S Adhiambo, A Adem, M Ochieng, A Otedo, K Otiende, A Odondi, F Makokha, D Lubanga, J Nyikui, W Masoso, M Manyonge, R Inginia, E Manuthu, D Wafula, C Agutu, R Malangachi, S Biko, null Simiyu, J Obare, D Kimutai, B Gituma, J Kyalo, M Timbwa, J Otieno, M Liru, C Nyabinda, S Otieno, R Aman, M Mwangangi, P Amoth, I Were, C Mwangi, K Kasera, W Ng’ang’a, A Tsegaye, C Sherry, B Singa, K Tickell, J Walson, J Berkley, F Were, N Mturi, M Hamaluba, B Tsofa, J Mwangangi, P Bejon, E Barasa, M English, A Nyaguara, EW Kagucia, JAG Scott, S Akech, AO Etyang, A Agweyu |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.10.25.22281489 |
| Popis: |
BackgroundThe impact of COVID-19 in Africa remains poorly defined. We sought to describe trends in hospitalisation due to all medical causes, pneumonia-specific admissions, and inpatient mortality in Kenya before and during the first five waves of the COVID-19 pandemic in Kenya.MethodsWe conducted a hospital-based, multi-site, longitudinal observational study of patients admitted to 13 public referral facilities in Kenya from January 2018 to December 2021. The pre-COVID population included patients admitted before 1 March 2020. We fitted time series models to compare observed and predicted trends for each outcome. To estimate the impact of the COVID-19 pandemic, we calculated incidence rate ratios (IRR) and corresponding 95% confidence intervals (CI) from negative binomial mixed-effects models.ResultsOut of 302,703 patients hospitalised across the 13 surveillance sites (range 11547 to 57011), 117642 (39%) were admitted to adult wards. Compared with the pre-COVID period, hospitalisations declined markedly among adult (IRR 0.68, 95% CI 0.63 to 0.73) and paediatric (IRR 0.67, 95% CI 0.62 to 0.73) patients. Adjusted in-hospital mortality also declined among both adult (IRR 0.83, 95% CI 0.77 to 0.89) and paediatric (IRR 0.85, 95% CI 0.77 to 0.94) admissions. Pneumonia-specific admissions among adults increased during the pandemic (IRR 1.75, 95% CI 1.18 to 2.59). Paediatric pneumonia cases were lower than pre-pandemic levels in the first year of the pandemic and elevated in late 2021 (IRR 0.78, 95% CI 0.51 to 1.20).ConclusionsContrary to initial predictions, the COVID-19 pandemic was associated with lower hospitalisation rates and in-hospital mortality, despite increased pneumonia admissions among adults. These trends were sustained after the withdrawal of containment measures that disrupted essential health services, suggesting a role for additional factors that warrant further investigation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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