Synthesis of novel pyridazine derivatives as potential antimicrobial agents

Autor:	Mohamed S. Behalo, Yvette Abd El-Sayed Issac, Iman A. Gad El-karim, Mohamed A. Elhadi Farag
Rok vydání:	2014
Předmět:	Pyridazine chemistry.chemical_compound chemistry Nucleophile Imidazolidine Isothiocyanate Thiazolidine Quinazoline Triazole Organic chemistry General Chemistry Antimicrobial
Zdroj:	Journal of Sulfur Chemistry. 35:661-673
ISSN:	1741-6000 1741-5993
DOI:	10.1080/17415993.2014.950661
Popis:	A series of novel pyridazine derivatives incorporated with triazole, thiazolidine, imidazolidine, oxazine, and quinazoline moieties was synthesized by the reaction of [6-(4-phenoxyphenyl)pyridazin-3-yloxy]acetyl isothiocyanate with variety of nucleophilic reagents. The structures of all products were confirmed and characterized by the elemental analysis and spectroscopic studies (IR, MS, 1H NMR). Also, the products were investigated for their antibacterial and antifungal activities and were compared with the standard drugs. Most of the synthesized compounds demonstrated potent to weak antimicrobial activity.
Databáze:	OpenAIRE
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