2-Methyl-2-propanthiol
| Autor: | Hartwig, Andrea, MAK Commission |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 2021 |
| Předmět: |
Mercaptane
mercaptans Lunge Toxizität liver maximum concentration at the workplace sensibilisierende Wirkung lung 2-methyl-2-propanethiol Odorierungszusatz sensitizing effects MAK‑Wert developmental toxicity tert-butyl mercaptan thiols tert-Butanthiol Leber Hautresorption Thiole Entwicklungstoxizität toxicity haematotoxicity skin absorption MAK value Hämatotoxizität tert-Butylmercaptan odouration additive maximale Arbeitsplatzkonzentration 2-methylpropane-2-thiol 2-Methyl-2-propanthiol |
| DOI: | 10.34865/mb7566d6_3or |
| Popis: | The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated data for 2-methyl-2-propanethiol [75-66-1] considering all toxicological end points. Data from a 90-day inhalation study with rats show that the critical effect of 2-methyl-2-propanethiol is its haematotoxic potential. On the basis of the NOAEC of 9 ml/m and taking into account the increased respiratory volume at the workplace, the maximum concentration at the workplace (MAK value) has been set at 1 ml/m. As the critical effect is systemic, Peak Limitation Category II has been assigned with an excursion factor of 2. The NOAEC for developmental toxicity was 11 ml/m in mice and 195 ml/m in rats. When the increased respiratory volume at the workplace is taken into consideration, a sufficient margin remains between the value determined for rats and the MAK value. In mice, the LOAEC for developmental toxicity was 99 ml/m and the NAEC is assumed to be above 11 ml/m; thus, there is a sufficient margin between the NAEC and the MAK value. Accordingly, damage to the embryo or foetus is unlikely when the MAK value is not exceeded and 2-methyl-2-propanethiol has been classified in Pregnancy Risk Group C. According to skin absorption models, percutaneous absorption is expected to contribute significantly to systemic toxicity. Therefore, 2-methyl-2-propanethiol has been designated with an “H”. 2-Methyl-2-propanethiol can cause sensitization of the skin in animals and has therefore been designated with “Sh”. 2-Methyl-2-propanethiol is not mutagenic in vitro or clastogenic in vivo and no studies in germ cells are available. No carcinogenicity studies have been performed. |
| Databáze: | OpenAIRE |
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