RGD Peptide as a Targeting Moiety for Theranostic Purpose: An Update Study
| Autor: | Saket Asati, Vikas Pandey, Vandana Soni |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
biology 010405 organic chemistry Chemistry Integrin Cancer Bioengineering Peptide Ligand (biochemistry) medicine.disease 01 natural sciences Biochemistry Molecular medicine 0104 chemical sciences Analytical Chemistry Endothelial stem cell Drug Discovery Cancer cell medicine Cancer research biology.protein Molecular Medicine Receptor |
| Zdroj: | International Journal of Peptide Research and Therapeutics. 25:49-65 |
| ISSN: | 1573-3904 1573-3149 |
| Popis: | In the current scenario, the utility of peptide as the targeting ligand has been increased for the efficient diagnosis and treatment of tumor cells. Blood vessels of tumor cells show some molecular receptors on the endothelial cell surface which can differentiate these cells from the remaining vasculature of other normal cells and tissues. Thus, these molecular receptors functioned as the revolutionary and striking target for the effective cancer diagnosis and treatment. Integrin (αvβ3) receptors are highly overexpressed onto the tumor neovasculature and tumor cells. Arginine-Glycine-Aspartic (RGD) peptide may be attached to these overexpressed integrin receptors with high affinity. Therefore, RGD-based systems have been developed for the effective delivery of diagnostic agent and anticancer drug for the diagnosis and treatment of cancer cells, respectively. In this review, an overview of peptide based nanoparticle especially RGD based nanoparticle systems in the field of theranostic application is provided. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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