Analgesic and anti-inflammatory effects of modafinil in a mouse model of neuropathic pain: A role for nitrergic and serotonergic pathways
| Autor: | Mahsa Rafeiean, Mehran Nematizadeh, Hossein Ghorbanzadeh, Ahmad Reza Dehpour, Parastoo Mohebkhodaei, Nastaran Rahimi, Mehdi Ghasemi |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Neurological Research. 44:390-402 |
| ISSN: | 1743-1328 0161-6412 |
| DOI: | 10.1080/01616412.2021.1992102 |
| Popis: | OBJECTIVES: To evaluate the effects of modafinil on neuropathic pain induced by sciatic nerve cuffing in mice, and possible contribution of nitrergic/inflammatory and serotonergic systems. METHODS: Neuropathic pain was induced by applying a polyethylene cuff around the left sciatic nerve. Seven days later, mice received modafinil (50, 100, and 200 mg/kg; intraperitoneal [i.p.]) and morphine (10 mg/kg, i.p.) as control. Mice also received pretreatments of the nonselective nitric oxide (NO) synthase (NOS) inhibitor L-NAME, the selective neuronal NOS inhibitor 7-nitroindazole, the selective inducible NOS inhibitor aminoguanidine, and the selective serotonin reuptake inhibitor citalopram before modafinil (100 mg/kg). von Frey test was used to evaluate mechanical allodynia. Additionally, sciatic nerves were collected for histopathological analysis. Tissue levels of NO metabolites, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were assessed. RESULTS: Animals whose sciatic nerves were cuffed had a significantly (P |
| Databáze: | OpenAIRE |
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