Selective O-difluoromethylation of 1,3-diones using S-(difluoromethyl) sulfonium salt
| Autor: | Jian-Jian Liu, Guo-Kai Liu, Xin Li, Wei-Feng Lin, Jia-Yi Chen, Li-Ting Lin, Wen-Bing Qin |
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| Rok vydání: | 2019 |
| Předmět: |
Reaction conditions
chemistry.chemical_classification Difluorocarbene Sulfonium Salt (chemistry) 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Medicinal chemistry Enol 0104 chemical sciences chemistry.chemical_compound chemistry 0210 nano-technology |
| Zdroj: | Chinese Chemical Letters. 30:1515-1518 |
| ISSN: | 1001-8417 |
| DOI: | 10.1016/j.cclet.2019.03.036 |
| Popis: | A facile and highly efficient approach for selective O-difluoromethylation of 1,3-diones by recently developed bench-stable S-(difluoromethyl)sulfonium salt was described. And a broad range of difluoromthyl enol ethers were readily accessed in good to excellent yields under mild reaction conditions. Mechanistic studies revealed that the O-difluoromethylation reaction proceeds mainly via a difluorocarbene pathway. |
| Databáze: | OpenAIRE |
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