Primary trabeculectomy with mitomycin C: safety and efficacy at 2 years
| Autor: | Olena Kubay, Rushmia Karim, Frances Booth, Jed A Lusthaus, David Wechsler |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Intraocular pressure Visual acuity genetic structures business.industry medicine.medical_treatment Glaucoma Retrospective cohort study Subgroup analysis Cataract surgery medicine.disease eye diseases Surgery Ophthalmology medicine Glaucoma surgery Trabeculectomy sense organs medicine.symptom business |
| Zdroj: | Clinical & Experimental Ophthalmology. 38:831-838 |
| ISSN: | 1442-6404 |
| DOI: | 10.1111/j.1442-9071.2010.02349.x |
| Popis: | Purpose: To examine the rates of intermediate-term intraocular pressure (IOP) control after trabeculectomy with adjunctive mitomycin C (MMC) and assess for associated complications. Methods: Medical records of patients undergoing primary trabeculectomy with MMC at Concord Repatriation Hospital, Sydney between January 1997 and December 2005 were reviewed. All eyes with a minimum of 2-year follow up were included. Follow-up data were collected in a standardized form on postoperative IOP, bleb-related and other complications. Success was measured as IOP ≤ 18 mmHg and ≥6 mmHg (criteria 1) with (qualified success) or without (absolute success) the use of glaucoma medications. A secondary outcome measure was an IOP reduction of greater than 20% from baseline (criteria 2). Eyes with preoperative IOP of 18 mmHg or less were included, but also analysed separately to those eyes with preoperative IOP above 18 mmHg. Results: Sixty eyes from 42 patients were included in the study, with 3-year follow up on 48 eyes. Mean preoperative IOP was 25.3 mmHg (range 8–45) and mean postoperative IOP was 14.0 mmHg at 1- and 2-year follow up, and 14.7 mmHg at 3 years (ranges: 3–31, 4–30 and 8–45 mmHg respectively). Cumulative success for criteria 1 was 85.0% at 2 years and 83.3% at 3 years, and for criteria 2 it was 80.0% and 79.2%, respectively. The number of eyes on glaucoma medications was reduced from 51 preoperatively to 30 at 3 years. Complications were infrequent. There was one eye with a shallow anterior chamber beyond the immediate postoperative period. One eye required cataract surgery at 1-year follow up. Subgroup analysis was performed using the first operated eye only, and results did not differ significantly from overall results. Conclusion: MMC-augmented trabeculectomy can significantly reduce IOP in the short and intermediate term, with a favourable safety profile. |
| Databáze: | OpenAIRE |
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