'Metabolic Reprogramming' in Ovarian Cancer Cells Resistant to Cisplatin

Autor:	Paola Dorigo, F Lonardoni, Eugenio Ragazzi, Laura Caparrotta, Stefano Mammi, Guglielmina Froldi, Monica Montopoli, Massimo Bellanda
Rok vydání:	2011
Předmět:	Pharmacology Cisplatin Cancer Research Cell Mitochondrion Biology Cell biology Mitochondrial respiratory chain medicine.anatomical_structure Oncology Cell culture Apoptosis Drug Discovery Cancer cell medicine Viability assay medicine.drug
Zdroj:	Current Cancer Drug Targets. 11:226-235
ISSN:	1568-0096
DOI:	10.2174/156800911794328501
Popis:	The way cancer cells escape cisplatin-induced apoptosis has not been completely elucidated yet. We questioned the relevance of "metabolic reprogramming" in cisplatin-resistance by studying mitochondrial function and metabolism in human ovarian carcinoma cell lines, both cisplatin-sensitive (2008) and resistant (C13). C13 cells, in comparison to 2008 cells, showed lower apoptotic response to cisplatin exposure, lower basal oxygen consumption (4.2±0.2 vs 6.5±0.7 fmol/cell/min, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::13b55762e7feabeae42d32cc7ba8ee27 https://doi.org/10.2174/156800911794328501 Zobrazit plný text záznamu