Synthesis by conventional methods of bovine and ovine growth hormone-(125–133)-nonapeptides

Autor:	F. Chillemi, V. R. Olgiati, R. Colombo, A. Pecile
Rok vydání:	1979
Předmět:	Acylation chemistry.chemical_classification Biochemistry Chemistry Biological activity Rat tibia Growth hormone Amino acid
Zdroj:	J. Chem. Soc., Perkin Trans. 1. :31-35
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19790000031
Popis:	Two nonapeptides, Arg-Glu-Leu-Glu-Asp-Gly-Thr-Pro-Arg and Arg-Glu-Leu-Glu-Asp-Val-Thr-Pro-Arg, corresponding to the sequence 125–133 of bovine and ovine growth hormones (BGH and OGH) were prepared by conventional methods. A stepwise procedure was applied, active ester and dicyclohexylcarbodi-imide were used in the acylation reactions, and all the protected intermediates were isolated and characterized for homogeneity. Both peptides synthesized by solution method and OGH-(125–133) previously prepared by a solid-phase method showed very low biological activity in the hypophysectomized rat tibia epiphyseal width test.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::13b4b59e644b8c8df628733a763c1f33 https://doi.org/10.1039/p19790000031 Zobrazit plný text záznamu