Effects of Levothyroxine Treatment on Lipid Profile in Subclinical Hypothyroidism: A Randomized Clinical Trial

Autor:	Karoon Shahebrahimi, Rozita Naseri, Tahereh Sadat Kalantarian, Mehrali Rahimi, Farid Najafi, Katayoun Derakhshandeh, Azam Sharifi
Rok vydání:	2015
Předmět:	lipids (amino acids peptides and proteins) General Medicine
Zdroj:	Galen Medical Journal. 4:72-77
ISSN:	2322-2379 2588-2767
DOI:	10.31661/gmj.v4i2.214
Popis:	Background: Studies demonstrated controversial results on subclinical hypothyroidism (SCH) regarding lipid profile alteration with or without Levothyroxine treatment. The purpose of this study is to investigate the effects of Levothyroxine on serum lipids in SCH. Materials and Methods: One hundred patients with SCH referred to Taleghani hospital in Kermanshah were recruited and randomly assigned into the intervention or the control group. Patients in intervention group received Levothyroxine 50-75 micrograms for three months. Patients in control group received the same placebo with the same dose and duration. Lipid profile was measured before and after the trial and the changes were compared between groups. (IRCT code: 138903244179N1). Results: Triglyceride, Total Cholesterol, LDL, HDL and Lipoprotein-A were measured before and after treatment. None of the factors showed significant difference either between or within groups, before and after the treatment (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::13ace4f803da3fe2d9ed1b1d2f8e70e3 https://doi.org/10.31661/gmj.v4i2.214 Zobrazit plný text záznamu