5-Fluorouracil and cisplatin as palliative treatment of advanced oesophageal squamous cell carcinoma

Autor:	Patrick Lozach, Jean-Marie Hay, Hugues Levard, Abe Fingerhut, Jacques Testart, Xavier Pouliquen, Michel Huguier, Odile Langlois-Zantain
Rok vydání:	2003
Předmět:	Chemotherapy medicine.medical_specialty Palliative care business.industry medicine.medical_treatment medicine.disease Chemotherapy regimen Surgery medicine.anatomical_structure Epidermoid carcinoma Fluorouracil medicine Carcinoma Esophagus business Lymph node medicine.drug
Zdroj:	European Journal of Surgery. 164:849-857
ISSN:	1741-9271 1102-4151
DOI:	10.1080/110241598750005273
Popis:	Objective: To compare chemotherapy with no chemotherapy as palliative treatment for oesophageal squamous cell carcinoma.Design: Randomised study.Setting: Multicentre trial in France.Subjects: Of 161 patients with histologically confirmed oesophageal squamous cell carcinoma located more than 5 cm from the mouth of the oesophagus, five were withdrawn because of protocol violation. The remaining 156 patients, 149 men and 7 women, mean (SD) age 58 (9) years range 36 to 77, were randomly allocated to either a control group without chemotherapy (n ≥ 84) or a group treated by chemotherapy (n ≥ 72). Patients were divided into four strata: I ≥ complete resection of the tumour but with lymph node involvement (n ≥ 62) ; II ≥ incomplete resection of tumour leaving gross tumour behind (n ≥ 58) ; III ≥ no resection because of local or regional invasion (n ≥ 22) ; and IV ≥ no resection because of distant metastasis (n ≥ 14). Exclusion criteria were histologically confirmed tracheobronchial involvement, oesophagotracheal...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::13a8c789ac12c0b77eaaca471e17710b https://doi.org/10.1080/110241598750005273 Zobrazit plný text záznamu