Cytotoxic, anti-HIV–1 and anti-inflammatory activities of lanostanes from fruits of Garcinia speciosa
| Autor: | Samran Prabpai, Vichai Reutrakul, Palangpon Kongsaeree, Jitra Limthongkul, Radeekorn Akkarawongsapat, Chutima Kuhakarn, Phanruethai Pailee, Sakchai Hongthong, Ampai Panthong, Thongchai Kruahong, Patoomratana Tuchinda, Manat Pohmakotr, Thaworn Jaipetch, Surawat Jariyawat, Kanoknetr Suksen |
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| Rok vydání: | 2017 |
| Předmět: |
Syncytium
010405 organic chemistry Stereochemistry medicine.drug_class Ethyl acetate Plant Science 01 natural sciences Biochemistry Lanostane Reverse transcriptase Anti-inflammatory 0104 chemical sciences Terpene 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Garcinia speciosa medicine Cytotoxic T cell Agronomy and Crop Science Biotechnology |
| Zdroj: | Phytochemistry Letters. 20:111-118 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2017.04.007 |
| Popis: | Bioassays-guided isolation of the hexanes and ethyl acetate extracts of the fruits of Garcinia speciosa led to the isolation of three new lanostane triterpenes 1–3 together with three related known derivatives 4–6. The new structures elucidated on the basis of spectroscopic and X-ray diffraction techniques were identified to be methyl (22E,24E)-9α-hydroxy-3-oxolanosta-22,24-dien-26-oate (1), (22E,24E)-9α,11β-dihydroxy-3-oxolanosta-22,24-dien-26-oic acid (2), and (24E)-23-acetoxy-3-oxolanosta-9,24-dien-26-oic acid (3), namely garciosaterpenes D, E and F, respectively. All compounds were evaluated for their cytotoxic and anti-inflammatory activities along with anti-HIV–1 activity. Most of the compounds were found inactive in the cytotoxic assay except for compound 6 which exhibited selective cytotoxicity against a KB cell line. All compounds showed significant inhibitory activities against HIV–1 reverse transcriptase (RT) assay and in the syncytium inhibition assay. Compounds 1, 5 and 6 displayed promising inhibitory activity in anti-inflammatory process. |
| Databáze: | OpenAIRE |
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