Differences in plasma concentration of acylethanolanydes and acylglycerols in paired samples of bipolar patients and first- and second-degree relatives
| Autor: | F.J. Pavón-Morón, P. Araos-Gómez, Pablo Romero-Sanchiz, Fermin Mayoral-Cleries, J. Guzman-Parra, M. Pedraz-Fernández, F. Rivas-Guerrero, A. Serrano-Criado, A. Pastor-Bosch, R. De la Torre-Fornell, F. Rodríguez de Fonseca |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Confounding Plasma levels medicine.disease Endocannabinoid system Psychiatry and Mental health Endocrinology Paired samples Close relationship Internal medicine Plasma concentration medicine Major depressive disorder Psychiatry Psychology Depression (differential diagnoses) |
| Zdroj: | European Psychiatry. 33:S340-S340 |
| ISSN: | 1778-3585 0924-9338 |
| DOI: | 10.1016/j.eurpsy.2016.01.1191 |
| Popis: | IntroductionEndocannabinoid System (ECS) has been highlighted as one of the most relevant research topics by neurobiologists, pharmacists, basic scientists and clinicians (Skaper and Di Marzo, 2012). Recent work has associated major depressive disorder with the ECS (Ashton and Moore, 2011). Despite the close relationship between depression and bipolar disorders, as far as we know, there is no characterization of ECS and congeners in a sample of patients with bipolar disorders.Aims and objectivesThe objective of this work is to characterize the plasma levels of endocannabinoids and congeners in a sample of patients with bipolar disorders.MethodThe clinical group was composed by 19 patients with a diagnosis of bipolar disorders using SCID-IV (First et al., 1999). The control group was formed by 18 relatives of first- or second-degree of the patients.The following endocannabinoids and congeners were quantified: N-palmitoleoylethanolamide (POEA), N-palmitolylethanolamide (PEA), N-oleoylethanolamide (OEA), N-stearoylethanolamide (SEA), N-arachidonoylethanolamide (AEA), N-dihomo-γ-linolenoylethanolamide (DGLEA), N-docosatetraenoylethanolamide (DEA), N-linoleoylethanolamide (LEA), N-docosahexaenoylethanolamide (DHEA), 2-arachidonoylglycerol (2-AG), 2-linoleoylglycerol (2-LG), and 2-oleoylglycerol (2-OG).ResultsThe result showed statistically significant lower levels of AEA, DEA and DHEA in clinical sample. Previous research also identified lower levels of AEA in depressed women (Hill et al., 2008, 2009). Until date, it is unknown if DEA and DHEA have some effect on EC receptors, and whether they have some direct effects on endocannabinoids.ConclusionsIt would be necessary to carry our other research with a larger sample, which could allow the control of potential confounding variables.Disclosure of interestThe authors have not supplied their declaration of competing interest. |
| Databáze: | OpenAIRE |
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