| Popis: |
After only a few human myeloma proteins were sequenced in the early 1960s, was it obvious that the human B cell repertoire displayed remarkable heterogeneity in that no two sequences were more than 85% identical. As murine proteins were sequenced in the late 1960s and early 1970s, more homogeneous structures were seen, and, as an understanding of the V, D, and J gene segments became apparent, it was obvious that, although rare, occasionally two independently derived murine myeloma protiens would be found with identical VH regions. At the present time, with well over 300 human and murine myelomas and hybridomas sequenced, it is still very unusual to find two VH regions that are identical. |
