| Popis: |
Parkinson disease (PD) is a common neurodegenerative disorder affecting 1% of the population aged seventy or more. The causes of PD remain obscure, but basic and clinical research has led to a deep insight into PD pathophysiology, identifying several points of intervention for emerging therapeutic strategies enabling modulation of neural circuits and replacement of lost neurons, neurotransmitters, and neurotrophic factors. ∈dent In this chapter we aim, accordingly, to present a overview of the current knowledge on PD pathophysiology and demonstrate how this knowledge provides targets for current and future pharmacological and surgical treatment strategies towards PD |
