Posttranslational and epigenetic regulation of the CLOCK/BMAL1 complex in the mammalian
| Autor: | Yool Lee, Kyungjin Kim |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Circadian clock Biology General Biochemistry Genetics and Molecular Biology Bacterial circadian rhythms Cell biology Endocrinology Internal medicine Negative feedback medicine Animal Science and Zoology Post-translational regulation Epigenetics Circadian rhythm Molecular clock Transcription factor |
| Zdroj: | Animal Cells and Systems. 16:1-10 |
| ISSN: | 2151-2485 1976-8354 |
| Popis: | Most living organisms synchronize their physiological and behavioral activities with the daily changes in the environment using intrinsic time-keeping systems called circadian clocks. In mammals, the key molecular features of the internal clock are transcription- and translational-based negative feedback loops, in which clock-specific transcription factors activate the periodic expression of their own repressors, thereby generating the circadian rhythms. CLOCK and BMAL1, the basic helix-loop-helix (bHLH)/PAS transcription factors, constitute the positive limb of the molecular clock oscillator. Recent investigations have shown that various levels of posttranslational regulation work in concert with CLOCK/BMAL1 in mediating circadian and cellular stimuli to control and reset the circadian rhythmicity. Here we review how the CLOCK and BMAL1 activities are regulated by intracellular distribution, posttranslational modification, and the recruitment of various epigenetic regulators in response to circadian and ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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