Formation of Colloidal Dispersions of Organic Materials in Aqueous Media by Solvent Shifting

Autor:	Harvey J. Palmer, Thomas H. Whitesides, M. Christine Brick
Rok vydání:	2003
Předmět:	Supersaturation Aqueous solution Chemistry Inorganic chemistry Aqueous two-phase system Surfaces and Interfaces Condensed Matter Physics Dilution Solvent Colloid Chemical engineering Electrochemistry General Materials Science Particle size Solubility Spectroscopy
Zdroj:	Langmuir. 19:6367-6380
ISSN:	1520-5827 0743-7463
DOI:	10.1021/la034173o
Popis:	This paper describes the preparation of colloidal dispersions of water-insoluble organic materials by a “solvent-shifting” procedure, in which a concentrated solution of an organic solute in a water-miscible organic solvent is dispersed into a large volume of aqueous (nonsolvent) bulk solution containing colloidal stabilizers. In the majority of cases studied, the solute separates as 0.1−0.5 μm amorphous particles. The particle size is strongly correlated with the local supersaturation, i.e., the ratio of the solute feed concentration to the instantaneous value of the equilibrium solubility in the bulk, and also shows a weak dependence on the solute feed concentration. The results obtained on systematic variation of the precipitation conditions, including the amount of organic solvent in the aqueous phase, the solute feed concentration, and the mixing conditions, are discussed in terms of a mechanism of particle formation comprising dispersion of the feed solution as small droplets, followed by solvent/wa...
Databáze:	OpenAIRE
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