Microwave accelerated three-component fluoroalkylations: expeditious routes to fluoropharmaceuticals and PET ligands

Autor:	Mathew Daniels, Patrick Ng, Michael S. Placzek, Luke Harris, Paul J. LaBeaume, Amy E. Kallmerten, Graham B. Jones
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Negishi coupling Organic Chemistry Late stage chemistry.chemical_element Sonogashira coupling Pet imaging Biochemistry chemistry Drug Discovery Microwave irradiation Fluorine Organic chemistry Alkyl Microwave
Zdroj:	Tetrahedron Letters. 52:332-335
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2010.11.056
Popis:	One-pot three-component coupling methods have been developed to allow in situ preparation of fluoroalkylated arenes and hydrocarbon chain analogs. The methods, which are accelerated under microwave irradiation gives access to ω-fluorinated alkyl, alkenyl, and alkynyl substituted arenes from readily available precursors. The methods involve late stage introduction of the fluorine and are well suited to application in the synthesis of 18F labeled PET imaging agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1394d28886ff50c54b09ac7c9d9816df https://doi.org/10.1016/j.tetlet.2010.11.056 Zobrazit plný text záznamu Full Text from ScienceDirect