Autor:	Peter F. M. Choong, Crispin R. Dass
Rok vydání:	2006
Předmět:	Cancer Research Liposome business.industry Vesicle Genetic enhancement Cancer Transferrin receptor Pharmacology medicine.disease Small molecule Oncology Drug delivery Genetics Medicine Cationic liposome business
Zdroj:	Cancer Cell International. 6:17
ISSN:	1475-2867
Popis:	Cationic (positively charged) liposomes have been tested in various gene therapy clinical trials for neoplastic and other diseases. They have demonstrated selectivity for tumour vascular endothelial cells raising hopes for both antiangiogenic and antivascular therapies. They are also capable of being selectively delivered to the lungs and liver when administered intravenously. These vesicles are being targeted to the tumour in various parts of the body by using advanced liposomal systems such as ligand-receptor and antibody-antigen combinations. At present, the transferrin receptor is commonly used for cancer-targeted drug delivery systems including cationic liposomes. This review looks at the growing utility of these vesicles for delivery of small molecule anticancer drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::13853ec09ec6d1e8b5aa5333ab128fc8 https://doi.org/10.1186/1475-2867-6-17 Zobrazit plný text záznamu Full text from SpringerLink