Regioselective one pot synthesis of 1,2,3-triazole derivatives bearing phthalazine moiety and their pharmacological activity
| Autor: | A. M. Vijesh, Balakrishna Kalluraya, S. K. Peethambar, P. C. Shyma |
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| Rok vydání: | 2016 |
| Předmět: |
1
2 3-Triazole 010405 organic chemistry Chemistry Organic Chemistry One-pot synthesis Biological activity 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Moiety Butylated hydroxytoluene Organic chemistry General Pharmacology Toxicology and Pharmaceutics Antibacterial activity Phthalazine Benzoic acid |
| Zdroj: | Medicinal Chemistry Research. 25:2680-2690 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-016-1629-4 |
| Popis: | A new series of phthalazine-based 1,2,3-triazole derivatives (5a–h, 6a–f and 7a–d) were synthesized from the corresponding 2-(4-methyl/chloro benzyloxy) benzoic acid by multi-step reactions. Synthesized compounds were characterized by spectral studies and C, H, N analysis. The final compounds were screened for their antimicrobial, antifungal and antioxidant activity. Among them compounds 5c, 5g, 5h, 6b and 6e showed good antibacterial activity as compared to the standard drug streptomycin,whereas compounds 5g and 6d showed good antifungal activity comparable to the standard drug Fluconazole. Compounds 5a, 5f and 7c showed significant antioxidant property when compared with the standard butylated hydroxytoluene. |
| Databáze: | OpenAIRE |
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