Mutagenic Activity of Acrolein inS. typhimurium andE. coli

Autor:	Richard H. C. San, Halina E. Caravello, Richard A. Parent
Rok vydání:	1996
Předmět:	endocrine system Salmonella Strain (chemistry) biology Acrolein food and beverages Toxicology medicine.disease_cause biology.organism_classification Enterobacteriaceae Microbiology chemistry.chemical_compound chemistry Toxicity medicine Cytotoxicity Escherichia coli Bacteria
Zdroj:	Journal of Applied Toxicology. 16:103-108
ISSN:	1099-1263 0260-437X
DOI:	10.1002/(sici)1099-1263(199603)16:2<103::aid-jat318>3.0.co;2-q
Popis:	Acrolein was tested for mutagenic activity in seven strains of Salmonella typhimurium and one strain of Escherichia coli using a preincubation assay procedure. Cytotoxicity was evident at dosing levels above 33 and 67 micrograms acrolein per plate in the absence and presence of S-9 activation, respectively. Evidence of mutagenic activity was seen at non-toxic dosing levels in S. typhimurium strains TA98 and TA100 and E. coli strain WP2 uvrA. Responses in TA98 and E. coli were marginal at best, but a firm positive mutagenic activity was noted in TA100 at 20 micrograms per plate without S-9 activation and at 67 micrograms per plate with S-9 activation. The results of this study demonstrate the mutagenicity of acrolein under highly controlled conditions.
Databáze:	OpenAIRE
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