Role of 5-HT1A receptors in the mediation of acute citalopram effects

Autor:	Annika Vaarmann, Lembit Allikmets, K. Pruus, R. Rudissaar, V. Matto
Rok vydání:	2002
Předmět:	Pharmacology medicine.medical_specialty 8-OH-DPAT Serotonin reuptake inhibitor Citalopram chemistry.chemical_compound Monoamine neurotransmitter Endocrinology chemistry Internal medicine medicine Serotonin Reuptake inhibitor Biological Psychiatry 5-HT receptor Behavioural despair test medicine.drug
Zdroj:	Progress in Neuro-Psychopharmacology and Biological Psychiatry. 26:227-232
ISSN:	0278-5846
DOI:	10.1016/s0278-5846(01)00253-6
Popis:	(1) The study was aimed to investigate the effects of the minimal effective doses of acute citalopram (5 mg/kg), (+/-)-8-hydroxydipropylaminotetralin HBr (8-OH-DPAT; 0.1 mg/kg), and their combined treatment on the rat open field and forced swimming behaviour and post-mortem monoamine content. (2) The animals were prospectively divided into the vehicle- and para-chlorophenylalanine (p-CPA)-pretreated (350 mg/kg) groups. (3) Acute citalopram (5 mg/kg), 8-OH-DPAT (0.1 mg/kg), or their combined treatment had no major effect on the rat open field and forced swimming behaviour. (4) The post-mortem catecholamine content in four brain regions studied was unchanged in all treatment groups. (5) The combined 8-OH-DPAT (0.1 mg/kg) and citalopram (5 mg/kg) treatment partially reversed the p-CPA-induced decrease of serotonin (5-HT) and 5-hydroxy-indolacetic acid (5-HIAA) content. (6) The present experiments demonstrate that the 5-HT1A receptors mediate some of the selective serotonin reuptake inhibitor (SSRI)-induced biochemical phenomena.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::13781e7e110dab298e5b8100c0c97e43 https://doi.org/10.1016/s0278-5846(01)00253-6 Zobrazit plný text záznamu Full Text from ScienceDirect