Capsular polysaccharide-protein conjugate vaccines

Autor:	Viliam Pavliak, Ramesh K. Sood, Ali Ibrahim Fattom, Robert B. Naso
Rok vydání:	1996
Předmět:	Pharmacology chemistry.chemical_classification Protective immunity biology Immunogenicity chemical and pharmacologic phenomena Polysaccharide biology.organism_classification Microbiology Immune system chemistry Carrier protein Drug Discovery Bacteria Conjugate
Zdroj:	Drug Discovery Today. 1:381-387
ISSN:	1359-6446
DOI:	10.1016/1359-6446(96)10032-5
Popis:	The conjugation of polysaccharides to carrier proteins generally enhances polysaccharide immunogenicity and renders the immune response T-cell dependent. Such enhancement of immunogenicity has made the use of conjugate vaccines possible in populations that are otherwise unresponsive to polysaccharide vaccines. Here, the authors discuss the value of capsular polysaccharide vaccines, their ability to elicit protective immunity against infectious bacteria, the selection of appropriate polysaccharides and carrier proteins, and the applications of the resultant conjugate vaccines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1374d3ba88d4ba1dc3fa892761a90a38 https://doi.org/10.1016/1359-6446(96)10032-5 Zobrazit plný text záznamu Full Text from ScienceDirect