Radical decarboxylative alkylation of tartaric acid

Autor:	Samir Z. Zard, Alice Gateau-Olesker, Derek H. R. Barton, B. Lacher, C. Tachdjian, Stephan D. Gero
Rok vydání:	1993
Předmět:	Addition reaction Organic Chemistry Photodissociation Free-radical reaction Alkylation Biochemistry Medicinal chemistry law.invention chemistry.chemical_compound chemistry law Dioxolane Drug Discovery Tartaric acid Organic chemistry Stereoselectivity Walden inversion
Zdroj:	Tetrahedron. 49:4589-4602
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)81288-6
Popis:	New derivatives of L-(+)-tartaric acid have been synthesized from the monomethyl-2,3-O-isopropylidene (R,R)-(+)-tartrate by visible light photolysis of its N-hydroxy-2-thiopyridone ester derivative in presence of activated alkenes. The carbon radical generated at the dioxolane ring adds stereoselectively to olefins to give the addition products with retention of configuration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::13694f6c085a706f1ffcad67e82aa225 https://doi.org/10.1016/s0040-4020(01)81288-6 Zobrazit plný text záznamu