Detection of retinal signals using position sensitive microelectrode arrays
| Autor: | E. J. Chichilnisky, J. Marchal, Val O'Shea, M. Rahman, M. Horn, J. J. Melone, Alan Litke, C. D. W. Wilkinson, R Tang, Deborah E. Gunning, Kevin M. Smith, Keith Mathieson, W. R. Cunningham |
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| Rok vydání: | 2003 |
| Předmět: |
Physics
Nuclear and High Energy Physics Retina Channel (digital image) Artificial neural network business.industry Retinal Multielectrode array Indium tin oxide Microelectrode chemistry.chemical_compound medicine.anatomical_structure chemistry Electrode medicine Optoelectronics business Instrumentation |
| Zdroj: | Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 513:51-56 |
| ISSN: | 0168-9002 |
| DOI: | 10.1016/s0168-9002(03)02135-1 |
| Popis: | The development of high-density, multi-channel circuitry for the detection of low-level signals in particle physics has potential application in other areas of science. Here we use this technology to study biological neural networks. For example understanding the code that the retina uses to process visual images is of great interest. To this end we have fabricated a 61-channel microelectrode array on the transparent conductor indium tin oxide. We analyse the effect of contact size on electrode characteristics and demonstrate the performance of these arrays in neurophysiological experiments using retinal tissue. We present some preliminary results in the development of 519 channel arrays to allow an increased area of the retina to be studied. |
| Databáze: | OpenAIRE |
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